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Effect of luminal pH on the output of bicarbonate and PGE by the normal human stomach

Gut, ISSN: 0017-5749, Vol: 28, Issue: 10, Page: 1291-1295
1987
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Article Description

The gastric output of bicarbonate and prostaglandin E has been calculated using a perfusion technique before and after instillation of 100 mM hydrochloric acid into the stomach of seven healthy volunteers. A significant increase in bicarbonate output occurred from 258±38 μmol/30 min during the basal period to 531±86 μmol/30 min after return of the intragastric pH to neutral (p<0.05). Prostaglandin E output also increased significantly from 410±136 pmol/30 min to 1002±194 pmol/30 min (p<0.05). The changes were caused mainly by an increase in gastric secretory volume with only non-significant increases in concentrations of bicarbonate and prostaglandin E The results suggest that mechanisms exist to adjust the rate of gastric bicarbonate secretion to the prevailing intraluminal pH and that this may occur through the release of prostaglandin E.

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