Effect of luminal pH on the output of bicarbonate and PGE by the normal human stomach
Gut, ISSN: 0017-5749, Vol: 28, Issue: 10, Page: 1291-1295
1987
- 18Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations18
- Citation Indexes18
- 18
- CrossRef14
- Captures3
- Readers3
Article Description
The gastric output of bicarbonate and prostaglandin E has been calculated using a perfusion technique before and after instillation of 100 mM hydrochloric acid into the stomach of seven healthy volunteers. A significant increase in bicarbonate output occurred from 258±38 μmol/30 min during the basal period to 531±86 μmol/30 min after return of the intragastric pH to neutral (p<0.05). Prostaglandin E output also increased significantly from 410±136 pmol/30 min to 1002±194 pmol/30 min (p<0.05). The changes were caused mainly by an increase in gastric secretory volume with only non-significant increases in concentrations of bicarbonate and prostaglandin E The results suggest that mechanisms exist to adjust the rate of gastric bicarbonate secretion to the prevailing intraluminal pH and that this may occur through the release of prostaglandin E.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023203373&origin=inward; http://dx.doi.org/10.1136/gut.28.10.1291; http://www.ncbi.nlm.nih.gov/pubmed/3479379; https://gut.bmj.com/lookup/doi/10.1136/gut.28.10.1291; https://dx.doi.org/10.1136/gut.28.10.1291; https://gut.bmj.com/content/28/10/1291
BMJ
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