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Long COVID and cardiovascular disease: a prospective cohort study

Open Heart, ISSN: 2053-3624, Vol: 11, Issue: 1
2024
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Studies from University College London (UCL) Update Current Data on COVID-19 (Long COVID and cardiovascular disease: a prospective cohort study)

2024 JUN 10 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx COVID-19 Daily -- Researchers detail new data in COVID-19. According to news

Article Description

Background Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known. Objectives To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors. Methods In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health. Results From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86). Conclusion Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.

Bibliographic Details

Lawson, Claire Alexandra; Moss, Alastair James; Arnold, Jayanth Ranjit; Bagot, Catherine; Banerjee, Amitava; Berry, Colin; Greenwood, John; Hughes, Alun D; Khunti, Kamlesh; Mills, Nicholas L; Neubauer, Stefan; Raman, Betty; Sattar, Naveed; Leavy, Olivia C; Richardson, Matthew; Elneima, Omer; McAuley, Hamish Jc; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Saunders, Ruth; Harris, Victoria; Houchen-Wolloff, Linzy; Greening, Neil J; Harrison, Ewen; Docherty, Annemarie B; Lone, Nazir I; Quint, Jennifer Kathleen; Chalmers, James; Ho, Ling-Pei; Horsley, Alex; Marks, Michael; Poinasamy, Krisnah; Evans, Rachael; Wain, Louise V; Brightling, Chris; McCann, Gerry P; PHOSP-COVID Study Collaborative Group

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