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Enteric coated microspheres of pancreatin in the treatment of cystic fibrosis: Comparison with a standard enteric coated preparation

Thorax, ISSN: 0040-6376, Vol: 42, Issue: 7, Page: 533-537
1987
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Article Description

In an open, randomised crossover study enteric coated microspheres of pancreatin were compared with a standard preparation of enteric coated pancreatin over two consecutive 28 day treatment periods in 23 adults with steatorrhoea due to cystic fibrosis. Lipase intake was equal to the patients' previous requirements and was the same during the two months. Patients performed 72 hour faecal collections at the end of each month and completed diary cards daily throughout. Comparison of the month of treatment with enteric coated microspheres with the month of standard enteric coated tablets showed a significant increase in body weight on microsphere capsules (p < 0.02). There was also a reduced frequency of bowel actions (p < 0.001) and abdominal pain (p < 0.05), and improvement in stool character (p < 0.001) on microsphere capsules. Faecal fat excretion was reduced by 44% with the microsphere capsules (p < 0.01), and 86% of patients showed an increased coefficient of fat absorption (mean increase 13%, 95% confidence limits 6.5-19.1%; p < 0.001). Eighty one per cent of patients preferred microsphere capsules of the two treatments. Thus enteric coated microsphere capsules are more effective in treating steatorrhoea in cystic fibrosis than standard enteric coated tablets.

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