PlumX Metrics
Embed PlumX Metrics

Lsh, a guardian of heterochromatin at repeat elements

Biochemistry and Cell Biology, ISSN: 0829-8211, Vol: 83, Issue: 4, Page: 548-554
2005
  • 55
    Citations
  • 0
    Usage
  • 51
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Conference Paper Description

Lymphoid-specific helicase (Lsh) is a crucial factor for normal embryonic development; targeted deletion of Lsh is lethal. Lsh belongs to a family of chromatin-remodeling proteins and is closely associated with pericentromeric heterochromatin. Lsh deficiency leads to abnormal heterochromatin organization, with a loss of DNA methylation, and an altered pattern of histone-tail acetylation and methylation. As a functional consequence of perturbed heterochromatin, aberrant reactivation of parasitic retroviral elements in the genome and abnormal mitosis with amplified centrosomes and genomic instability were observed. Thus, Lsh is a major epigenetic regulator crucial for normal heterochromatin structure and function. © 2005 NRC.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know