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Pathways for compartmentalizing protein synthesis in eukaryotic cells: The template-partitioning model

Biochemistry and Cell Biology, ISSN: 0829-8211, Vol: 83, Issue: 6, Page: 687-695
2005
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Conference Paper Description

mRNAs encoding signal sequences are translated on endoplasmic reticulum (ER) - bound ribosomes, whereas mRNAs encoding cytosolic proteins are translated on cytosolic ribosomes. The partitioning of mRNAs to the ER occurs by positive selection; cytosolic ribosomes engaged in the translation of signal-sequence-bearing proteins are engaged by the signal-recognition particle (SRP) pathway and subsequently trafficked to the ER. Studies have demonstrated that, in addition to the SRP pathway, mRNAs encoding cytosolic proteins can also be partitioned to the ER, suggesting that RNA partitioning in the eukaryotic cell is a complex process requiring the activity of multiple RNA-partitioning pathways. In this review, key findings on this topic are discussed, and the template-partitioning model, describing a hypothetical mechanism for RNA partitioning in the eukaryotic cell, is proposed. © 2005 NRC.

Bibliographic Details

Nicchitta, Christopher V; Lerner, Rachel S; Stephens, Samuel B; Dodd, Rebecca D; Pyhtila, Brook

Canadian Science Publishing

Biochemistry, Genetics and Molecular Biology

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