Adrenal 11-beta hydroxysteroid dehydrogenase activity in response to stress
Canadian Journal of Physiology and Pharmacology, ISSN: 0008-4212, Vol: 82, Issue: 6, Page: 422-425
2004
- 12Citations
- 8Captures
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Metrics Details
- Citations12
- Citation Indexes12
- 12
- CrossRef8
- Captures8
- Readers8
Article Description
This work studied the effect of stresses produced by simulated gavage or gavage with 200 mmol/L HCl two hours before adrenal extraction, on the activities of the 11β-hydroxysteroid dehydrogenase 1 and 11β-hydroxysteroid dehydrogenase 2 isoforms present in the rat adrenal gland. These activities were determined on immediately prepared adrenal microsomes following incubations with H-corticosterone and NAD or NADP. 11-dehydrocorticosterone was measured as an end-product by TLC, and controls were adrenal microsomes from rats kept under basal (unstressed) conditions. 11β-hydroxysteroid dehydrogenase 1 activity, but not 11β-hydroxysteroid dehydrogenase 2 activity, was increased under both stress-conditions. Homeostatically, the stimulation of 11β- hydroxysteroid dehydrogenase 1 activity would increase the supply of glucocorticoids. These, in turn, would activate the enzyme phenylethanolamine N-methyl transferase, thereby improving the synthesis of epinephrine as part of the stress-response.
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