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Effect of bovine serum albumin on the water solubility of hydrophobic corrinoids

Journal of Porphyrins and Phthalocyanines, ISSN: 1099-1409, Vol: 27, Issue: 5, Page: 811-817
2023
  • 4
    Citations
  • 0
    Usage
  • 1
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    4
  • Captures
    1
  • Mentions
    1
    • News Mentions
      1
      • 1

Most Recent News

Studies from Ivanovo State University Yield New Information about Bovine Serum Albumin (Effect of Bovine Serum Albumin On the Water Solubility of Hydrophobic Corrinoids)

2023 JUN 28 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Life Science Daily -- Current study results on Proteins - Bovine Serum

Article Description

Medicinal effects of hydrophobic derivatives of vitamin B12 have been insignificantly investigated primarily due to their low solubility in aqueous solutions. One of the ways to increase their water solubility is the complexation with proteins. Here, we report the results of the studies of the reactions between aquacyano cobyrinic acid or monocyano cobesters (i.e., heptamethyl, heptaethyl, heptapropyl, and heptabutyl cobyrinates) and bovine serum albumin (BSA). The weakest binding is observed between aquacyano cobyrinic acid and BSA. In the case of monocyano heptaethyl cobyrinate, one BSA molecule is capable of binding up to six corrinoid molecules preventing its precipitation. Moreover, the pronounced effect of BSA on the solubility in water was observed in the case of monocyano heptapropyl cobyrinate. The absence of the precipitation of monocyano heptabutyl cobyrinate was observed only in the presence of high excess of BSA. BSA modification by diethyl pyrocarbonate, a chemical predominantly reactive toward imidazole motifs, indicated that a major fraction of BSA is bound with monocyano heptaethyl, heptapropyl, and heptabutyl cobyrinates via histidine residues. We showed that nitrosyl complexes of heptaethyl and heptapropyl cobyrinates can be stabilized from precipitation in aqueous solutions using BSA.

Bibliographic Details

Ilia A. Dereven'kov; Ilya I. Dzvinkas; Vladimir S. Osokin; Sergei V. Makarov

World Scientific Pub Co Pte Ltd

Chemistry

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