The Epithelial-to-Mesenchymal Transition in Development and Cancer
Annual Review of Cancer Biology, ISSN: 2472-3428, Vol: 4, Issue: 1, Page: 197-220
2020
- 51Citations
- 97Captures
- 3Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations51
- Citation Indexes51
- 51
- CrossRef49
- Captures97
- Readers97
- 97
- Mentions3
- References3
- Wikipedia3
Review Description
Epithelial-to-mesenchymal transitions (EMTs) are complex cellular processes where cells undergo dramatic changes in signaling, transcriptional programming, and cell shape, while directing the exit of cells from the epithelium and promoting migratory properties of the resulting mesenchyme. EMTs are essential for morphogenesis during development and are also a critical step in cancer progression and metastasis formation. Here we provide an overview of the molecular regulation of the EMT process during embryo development, focusing on chick and mouse gastrulation and neural crest development. We go on to describe how EMT regulators participate in the progression of pancreatic and breast cancer in mouse models, and discuss the parallels with developmental EMTs and how these help to understand cancer EMTs. We also highlight the differences between EMTs in tumor and in development to arrive at a broader view of cancer EMT. We conclude by discussing how further advances in the field will rely on in vivo dynamic imaging of the cellular events of EMT.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85084115613&origin=inward; http://dx.doi.org/10.1146/annurev-cancerbio-030518-055425; http://www.ncbi.nlm.nih.gov/pubmed/34113749; https://www.annualreviews.org/doi/10.1146/annurev-cancerbio-030518-055425; https://dx.doi.org/10.1146/annurev-cancerbio-030518-055425
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