Phosphorylation of RyR and shortening of RyR cluster spacing in spontaneously hypertensive rat with heart failure
American Journal of Physiology - Heart and Circulatory Physiology, ISSN: 0363-6135, Vol: 293, Issue: 4, Page: H2409-17
2007
- 44Citations
- 41Captures
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Metrics Details
- Citations44
- Citation Indexes44
- 44
- CrossRef33
- Captures41
- Readers41
- 41
Article Description
As a critical step toward understanding the role of abnormal intracellular Ca release via the ryanodine receptor (RyR) during the development of hypertension-induced cardiac hypertrophy and heart failure, this study examines two questions: 1) At what stage, if ever, in the development of hypertrophy and heart failure is RyR hyperphosphorylated at Ser ? 2) Does the spatial distribution of RyR clusters change in failing hearts? Using a newly developed semiquantitative immunohistochemistry method and Western blotting, we measured phosphorylation of RyR at Ser in the spontaneously hypertensive rat (SHR) at four distinct disease stages. A major finding is that hyperphosphorylation of RyR at Ser occurred only at late-stage heart failure in SHR, but not in age-matched controls. Furthermore, the spacing between RyR clusters was shortened in failing hearts, as predicted by quantitative model simulation to increase spontaneous Ca wave generation and arrhythmias. Copyright © 2007 the American Physiological Society.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=35348971380&origin=inward; http://dx.doi.org/10.1152/ajpheart.00562.2007; http://www.ncbi.nlm.nih.gov/pubmed/17630346; https://www.physiology.org/doi/10.1152/ajpheart.00562.2007; http://ajpheart.physiology.org/cgi/doi/10.1152/ajpheart.00562.2007; http://ajpheart.physiology.org/content/293/4/H2409
American Physiological Society
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