Extracellular microRNA signature in chronic kidney disease
American Journal of Physiology - Renal Physiology, ISSN: 1522-1466, Vol: 312, Issue: 6, Page: F982-F991
2017
- 47Citations
- 18Usage
- 72Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations47
- Citation Indexes46
- 46
- CrossRef30
- Patent Family Citations1
- Patent Families1
- Usage18
- Abstract Views18
- Captures72
- Readers72
- 72
Article Description
MicroRNAs (miRNAs) are noncoding RNAs that regulate posttranscriptional gene expression. In this study we characterized the circulating and urinary miRNA pattern associated with reduced glomerular filtration rate, using Affymetrix GeneChip miR 4.0 in 28 patients with chronic kidney disease (CKD). Top miRNA discoveries from the human studies were validated in an Alb/TGFβ mouse model of CKD, and in rat renal proximal tubular cells (NRK52E) exposed to TGFβ1. Plasma and urinary levels of procollagen III N-terminal propeptide and collagen IV were elevated in patients with decreased estimated glomerular filtration rate (eGFR). Expression of 384 urinary and 266 circulatory miRNAs were significantly different between CKD patients with eGFR ≥30 vs. <30 mlmin 1.73 m. Pathway analysis mapped multiple miRNAs to TGFβ signaling-related mRNA targets. Specifically, Let-7a was significantly downregulated, and miR-130a was significantly upregulated, in urine of patients with eGFR <30; miR-1825 and miR-1281 were upregulated in both urine and plasma of patients with decreased eGFR; and miR-423 was significantly downregulated in plasma of patients with decreased eGFR. miRNA expression in urine and plasma of Alb/TGFβ mice generally resembled and confirmed most, although not all, of the observations from the human studies. In response to TGFβ1 exposure, rat renal proximal tubular cells overexpressed miR-1825 and downregulated miR-423. Thus, miRNA are associated with kidney fibrosis, and specific urinary and plasma miRNA profile may have diagnostic and prognostic utility in CKD.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85020079272&origin=inward; http://dx.doi.org/10.1152/ajprenal.00569.2016; http://www.ncbi.nlm.nih.gov/pubmed/28077372; https://www.physiology.org/doi/10.1152/ajprenal.00569.2016; https://hsrc.himmelfarb.gwu.edu/sphhs_exer_facpubs/107; https://hsrc.himmelfarb.gwu.edu/cgi/viewcontent.cgi?article=1108&context=sphhs_exer_facpubs; http://ajprenal.physiology.org/lookup/doi/10.1152/ajprenal.00569.2016; http://ajprenal.physiology.org/content/312/6/F982
American Physiological Society
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