Identification of temporal patterns of gene expression in the uteri of immature, ovariectomized mice following exposure to ethynylestradiol
Physiological Genomics, ISSN: 1531-2267, Vol: 15, Issue: 2, Page: 127-141
2004
- 53Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations53
- Citation Indexes53
- 53
- CrossRef43
- Captures9
- Readers9
Article Description
Estrogen induction of uterine wet weight provides an excellent model to investigate relationships between changes in global gene expression and well-characterized physiological responses. In this study, time course microarray GeneChip data were analyzed using a novel approach to identify temporal changes in uterine gene expression following treatment of immature ovariectomized C57BL/6 mice with 0.1 mg/kg 17α-ethynylestradiol. Functional gene annotation information from public databases facilitated the association of changes in gene expression with physiological outcomes, which allowed detailed mechanistic inferences to be drawn regarding cell cycle control and proliferation, transcription and translation, structural tissue remodeling, and immunologic responses. These systematic approaches confirm previously established responses, identify novel estrogen-regulated transcriptional effects, and disclose the coordinated activation of multiple modes of action that support the uterotrophic response elicited by estrogen. In particular, it was possible to elucidate the physiological significance of the dramatic induction of arginase, a classic estrogenic response, by elucidating its mechanistic relevance and delineating the role of arginine and ornithine utilization in the estrogen-stimulated induction of uterine wet weight.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0346502713&origin=inward; http://dx.doi.org/10.1152/physiolgenomics.00058.2003; http://www.ncbi.nlm.nih.gov/pubmed/12915738; https://www.physiology.org/doi/10.1152/physiolgenomics.00058.2003; http://physiolgenomics.physiology.org/lookup/doi/10.1152/physiolgenomics.00058.2003; http://physiolgenomics.physiology.org/content/15/2/127; http://physiolgenomics.physiology.org/content/15/2/127.abstract; http://physiolgenomics.physiology.org/content/physiolgenomics/15/2/127.full.pdf; http://physiolgenomics.physiology.org/cgi/doi/10.1152/physiolgenomics.00058.2003; http://www.physiology.org/doi/10.1152/physiolgenomics.00058.2003
American Physiological Society
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