Evaluation of hepcidin isoforms in hemodialysis patients by a proteomic approach based on SELDI-TOF MS
Journal of Biomedicine and Biotechnology, ISSN: 1110-7243, Vol: 2010, Page: 329646
2010
- 37Citations
- 20Captures
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Metrics Details
- Citations37
- Citation Indexes37
- 37
- CrossRef26
- Captures20
- Readers20
- 20
Article Description
The hepatic iron regulator hormone hepcidin consists, in its mature form, of 25 amino acids, but two other isoforms, hepcidin-20 and hepcidin-22, have been reported, whose biological meaning remains poorly understood. We evaluated hepcidin isoforms in sera from 57 control and 54 chronic haemodialysis patients using a quantitative proteomic approach based on SELDI-TOF-MS. Patients had elevated serum levels of both hepcidin-25 and hepcidin-20 as compared to controls (geometric means: 7.52 versus 4.69nM, and 4.06 versus 1.76nM, resp., P <.05 for both). The clearance effects of a single dialysis session by different dialysis techniques and membranes were also investigated, showing an average reduction by 51.3% ± 29.2% for hepcidin-25 and 34.2% ± 28.4% for hepcidin-20 but only minor differences among the different dialysis modalities. Measurement of hepcidin isoforms through MS-based techniques can be a useful tool for better understanding of their biological role in hemodialysis patients and other clinical conditions. © 2010 Natascia Campostrini et al.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952502655&origin=inward; http://dx.doi.org/10.1155/2010/329646; http://www.ncbi.nlm.nih.gov/pubmed/20414466; http://www.hindawi.com/journals/bmri/2010/329646/; https://dx.doi.org/10.1155/2010/329646; https://www.hindawi.com/journals/bmri/2010/329646/
Hindawi Limited
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