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Flow-injection preconcentration of chloramphenicol using molecularly imprinted polymer for HPLC determination in environmental samples

Journal of Automated Methods and Management in Chemistry, ISSN: 1463-9246, Vol: 2011, Page: 143416
2011
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The residue of antibiotic chloramphenicol (CAP) is important issue for food quality control and also for the environmental monitoring. It is banned for use in food-producing animals and has very limited use in human medicine, because of its severe impact on human health. Determination of trace level of CAP in environmental samples requires a very sensitive analytical method and efficient preconcentration procedure. CAP can be efficiently preconcentrated in flow-injection system using flow-through reactor packed with molecularly imprinted polymer (MIP), but determination of CAP in eluate from MIP requires the application of chromatographic separation, which was made in reversed-phase HPLC system with UV detection. In optimized conditions the limit of detection for 100mL sample in HPLC with offline preconcentration on MIP was evaluated as 0.66mg/L. In hyphenated FIA-HPLC system with zone sampling the LOD for developed method was evaluated as 15ng/L, which indicates the possibility of using it for analysis of environmental samples. Copyright © 2011 Damian Kowalski et al.

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