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Integrated Stress Response as a Therapeutic Target for CNS Injuries

BioMed Research International, ISSN: 2314-6141, Vol: 2017, Page: 6953156
2017
  • 79
    Citations
  • 0
    Usage
  • 50
    Captures
  • 0
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    79
  • Captures
    50
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Review Description

Central nervous system (CNS) injuries, caused by cerebrovascular pathologies or mechanical contusions (e.g., traumatic brain injury, TBI) comprise a diverse group of disorders that share the activation of the integrated stress response (ISR). This pathway is an innate protective mechanism, with encouraging potential as therapeutic target for CNS injury repair. In this review, we will focus on the progress in understanding the role of the ISR and we will discuss the effects of various small molecules that target the ISR on different animal models of CNS injury.

Bibliographic Details

Romero-Ramírez, Lorenzo; Nieto-Sampedro, Manuel; Barreda-Manso, M Asunción

Hindawi Limited

Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology

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