Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice
Cancer Research, ISSN: 0008-5472, Vol: 64, Issue: 14, Page: 5020-5027
2004
- 51Citations
- 24Captures
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Metrics Details
- Citations51
- Citation Indexes51
- 51
- CrossRef44
- Captures24
- Readers24
- 24
Article Description
Shaved male or female p53(-/-) C57BL/6J mice and their wild-type littermates were irradiated once with UVB (60 mJ/cm). The UVB-induced increase in apoptotic sunburn cells in p53(-/-) mice at 6-10 h after exposure to UVB was only 10-30% of that observed after treatment of p53(+/+) mice with UVB. Topical applications of caffeine immediately after UVB irradiation in female p53(+/+) or p53(-/-) mice enhanced the UVB-induced increase in apoptotic sunburn cells 6 h later by 127% and 563%, respectively. In another study, shaved female Bax(-/-) C57BL/6J mice and their wild-type littermates were irradiated once with UVB (60 mJ/cm). The UVB-induced increase in apoptotic sunburn cells in Bax(-/-) mice at 6 h after exposure to UVB was only 14% of that observed after treatment of Bax(+/+) mice with UVB. Topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increases in apoptotic sunburn cells at 6 h by 214% and 467%, respectively, and topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increase in caspase 3 (active form) positive cells at 6 h by 253% and 750%, respectively. The results indicate that UVB-induced increases in apoptosis in the epidermis of wild-type mice are predominantly (but not entirely) by p53- and Bax-dependent pathways and that topical application of caffeine can enhance UVB-induced increases in apoptosis by p53- and Bax-independent pathways.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=3142704344&origin=inward; http://dx.doi.org/10.1158/0008-5472.can-04-0760; http://www.ncbi.nlm.nih.gov/pubmed/15256477; https://aacrjournals.org/cancerres/article/64/14/5020/511461/Stimulatory-Effect-of-Topical-Application-of; http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-5472.CAN-04-0760; https://syndication.highwire.org/content/doi/10.1158/0008-5472.CAN-04-0760; https://dx.doi.org/10.1158/0008-5472.can-04-0760; https://cancerres.aacrjournals.org/content/64/14/5020
American Association for Cancer Research (AACR)
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