Timing is everything: Misincorporation of 8oxodg during mitosis is lethal
Cancer Research, ISSN: 1538-7445, Vol: 80, Issue: 17, Page: 3459-3460
2020
- 8Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Captures8
- Readers8
Article Description
Exploiting universal cancer vulnerabilities has been used as an approach for developing targeted therapies. In this issue of Cancer Research, Rudd and colleagues show that the dual-functioning inhibitor TH588 potentiates the accumulation of reactive oxygen species during mitosis in cancer by disturbing mitotic progression and simultaneously inhibiting the hydrolysis of 8oxodGTP. This leads to increased incorporation of 8oxodG into the DNA during mitotic replication and increased toxicity. Understanding the mechanism of this inhibitor lays the groundwork for identifying cancer targets.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85100341921&origin=inward; http://dx.doi.org/10.1158/0008-5472.can-20-1904; http://www.ncbi.nlm.nih.gov/pubmed/32878864; https://aacrjournals.org/cancerres/article/80/17/3459/645825/Timing-Is-Everything-Misincorporation-of-8oxodG; https://dx.doi.org/10.1158/0008-5472.can-20-1904; https://cancerres.aacrjournals.org/content/80/17/3459
American Association for Cancer Research (AACR)
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