Multiparametric detection of antibodies against different EBV antigens to predict risk for nasopharyngeal carcinoma in a high-risk population of China
Cancer Prevention Research, ISSN: 1940-6215, Vol: 10, Issue: 9, Page: 542-550
2017
- 11Citations
- 20Captures
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef10
- Captures20
- Readers20
- 20
Article Description
In this study, we aimed to use the combineddetectionofmultiple antibodies against Epstein-Barr virus (EBV) antigens to develop a model for screening and diagnosis of nasopharyngeal carcinoma (NPC). Samples of 300 nasopharyngeal carcinoma patients and 494 controls, including 294 healthy subjects (HC), 99 non-nasopharyngeal carcinoma cancer patients (NNPC), and 101 patients with benign nasopharyngeal lesions (BNL), were incubated with the EUROLINE Anti-EBV Profile 2, and band intensities were used to establish a risk predictionmodel. The nasopharyngeal carcinoma risk probability analysis based on the panel of VCAgp125 IgA, EBNA-1 IgA, EA-D IgA, EBNA-1 IgG, EAD IgG, and VCAp19 IgG displayed the best performance. When using 26.1% as the cutoff point in ROC analysis, the AUC value and sensitivity/specificity were 0.951 and 90.7%/86.2%, respectively, in nasopharyngeal carcinoma and all controls. In nasopharyngeal carcinoma and controls without the non-nasopharyngeal carcinoma and BNL groups, the AUC value and sensitivity/specificity were 0.957 and 90.7%/88.1%, respectively. The diagnostic specificity and sensitivity of the EUROLINE Anti-EBV Profile 2 assay for both nasopharyngeal carcinoma and early-stage nasopharyngeal carcinoma were higher than that of mono-antibody detection by immune-enzymatic assay and real-time PCR(EBVDNA). In theVCA-IgA-negative group, 82.6% of nasopharyngeal carcinoma patients showed high probability for nasopharyngeal carcinoma, and the negative predictive value was 97.1%. In the VCA-IgA-positive group, 73.3% of healthy subjects showed low probability. The positive predictive value reached 98.2% in this group. The nasopharyngeal carcinoma risk probability value determined by the EUROLINE Anti-EBV Profile 2 might be a suitable tool for nasopharyngeal carcinoma screening. Cancer Prev Res; 10(9); 542-50.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85029484838&origin=inward; http://dx.doi.org/10.1158/1940-6207.capr-17-0035; http://www.ncbi.nlm.nih.gov/pubmed/28754665; http://cancerpreventionresearch.aacrjournals.org/lookup/doi/10.1158/1940-6207.CAPR-17-0035; https://syndication.highwire.org/content/doi/10.1158/1940-6207.CAPR-17-0035; https://aacrjournals.org/cancerpreventionresearch/article/10/9/542/46907/Multiparametric-Detection-of-Antibodies-against; https://dx.doi.org/10.1158/1940-6207.capr-17-0035
American Association for Cancer Research (AACR)
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