CD8PD-1ILT2 T cells are an intratumoral cytotoxic population selectively inhibited by the immune-checkpoint HLA-G
Cancer Immunology Research, ISSN: 2326-6074, Vol: 7, Issue: 10, Page: 1619-1632
2019
- 60Citations
- 58Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations60
- Citation Indexes59
- 59
- CrossRef37
- Patent Family Citations1
- Patent Families1
- Captures58
- Readers58
- 58
Article Description
Only some cancer patients respond to the immune-checkpoint inhibitors being used in the clinic, and other therapeutic targets are sought. Here, we investigated the HLA-G/ILT2 checkpoint in clear-cell renal-cell carcinoma (ccRCC) patients and focused on tumor-infiltrating CD8 T lymphocytes (TIL) expressing the HLA-G receptor ILT2. Using transcriptomics and flow cytometry, we characterized both peripheral blood and tumor-infiltrating CD8ILT2 T cells from cancer patients as late-differentiated CD27CD28CD57 cytotoxic effectors. We observed a clear dichotomy between CD8ILT2 and CD8PD-1 TIL subsets. These subsets, which were sometimes present at comparable frequencies in TIL populations, barely overlapped phenotypically and were distinguished by expression of exclusive sets of surface molecules that included checkpoint molecules and activating and inhibitory receptors. CD8ILT2 TILs displayed a more mature phenotype and higher expression of cytotoxic molecules. In ex vivo functional experiments with both peripheral blood T cells and TILs, CD8ILT2 T cells displayed significantly higher cytotoxicity and IFNg production than their ILT2 (peripheral blood mononuclear cells, PBMC) and PD-1 (TILs) counterparts. HLA-G expression by target cells specifically inhibited CD8ILT2 T-cell cytotoxicity, but not that of their CD8ILT2(PBMC) or CD8PD-1 (TIL) counterparts, an effect counteracted by blocking the HLA-G/ILT2 interaction. CD8ILT2 TILs may therefore constitute an untapped reservoir of fully differentiated cytotoxic T cells within the tumor microenvironment, independent of the PD1 TILs targeted by immune therapies, and specifically inhibited by HLA-G. These results emphasize the potential of therapeutically targeting the HLA-G/ILT2 checkpoint in HLA-G tumors, either concomitantly with anti–PD-1/PD-L1 or in cases of nonresponsiveness to anti–PD-1/PD-L1.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85072849310&origin=inward; http://dx.doi.org/10.1158/2326-6066.cir-18-0764; http://www.ncbi.nlm.nih.gov/pubmed/31451484; https://aacrjournals.org/cancerimmunolres/article/7/10/1619/466822/CD8-PD-1-ILT2-T-Cells-Are-an-Intratumoral; https://dx.doi.org/10.1158/2326-6066.cir-18-0764; https://cancerimmunolres.aacrjournals.org/content/7/10/1619
American Association for Cancer Research (AACR)
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