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Drug-induced depression: A systematic review to inform clinical practice

Psychotherapy and Psychosomatics, ISSN: 0033-3190, Vol: 73, Issue: 4, Page: 207-215
2004
  • 112
    Citations
  • 0
    Usage
  • 126
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    112
  • Captures
    126
  • Mentions
    1
    • References
      1
      • 1

Review Description

Background: Certain medications may contribute to the etiology of depressive symptoms and disorders. Research in this area, however, has been hampered by methodological and conceptual problems. This review had two objectives: to identify evidence linking medical drugs to depressive symptoms and disorders, and to summarize this evidence in a clinically meaningful way. Methods: Electronic literature searches were performed and studies were reviewed with reference to critical methodological features. Results: No medications causing the typical major depressive syndrome were identified. Evidence was found linking corticosteroids, interferon-α, interleukin-2, gonadotropin-releasing hormone agonists, mefloquine, progestin-releasing implanted contraceptives and propranolol to the etiology of atypical depressive syndromes. Conclusions: A small number of drugs have been shown capable of inducing depressive symptoms. Drug-induced depression appears to differ symptomatically from classical major depression. Copyright © 2004 S. Karger AG, Basel.

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