Anti-prothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome a systematic review
Thrombosis and Haemostasis, ISSN: 0340-6245, Vol: 111, Issue: 2, Page: 354-364
2013
- 207Citations
- 117Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations207
- Citation Indexes206
- 206
- CrossRef181
- Clinical Citations1
- PubMed Guidelines1
- Captures117
- Readers117
- 117
Article Description
Antibodies to prothrombin are detected by directly coating prothrom-bin on irradiated ELISA plates (aPT) or by using the phosphatidylser-ine/prothrombin complex as antigen (aPS/PT). Although these antibodies have both been associated with antiphospholipid syndrome (APS) and a correlation between the two assays have been reported, it seems that aPT and aPS/PT belong to different populations of auto-antibodies. It was our objective to systematically review the available evidence on aPT and aPS/PT antibodies and the risk of thrombosis in APS. Medline-reports published between 1988 and 2013 investigating aPT and aPS/PT as a risk factor for thrombosis were included. Whenever possible, antibody isotype(s) and site of thrombosis were analysed. This systematic review is based on available data from more than 7,000 patients and controls from 38 studies analysing aPT and 10 aPS/PT. Antibodies to prothrombin (both aPT and aPS/PT) increased the risk of thrombosis (odds ratio [OR] 2.3; 95% confidence interval [CI] 1.72-3.5). aPS/PT seemed to represent a stronger risk factor for thrombosis, both arterial and/or venous than aPT (OR 5.11; 95%CI 4.2-6.3 and OR 1.82; 95%CI 1.44-2.75, respectively). In conclusion, routine measurement of aPS/PT (but not aPT) might be useful in establishing the thrombotic risk of patients with previous thrombosis and/or systemic lupus erythematosus. Their inclusion as laboratory criteria for the APS should be indisputably further explored. © Schattauer 2014.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84893175081&origin=inward; http://dx.doi.org/10.1160/th13-06-0509; http://www.ncbi.nlm.nih.gov/pubmed/24172938; http://www.schattauer.de/index.php?id=1214&doi=10.1160/TH13-06-0509; http://www.schattauer.de/index.php?id=5236&mid=20459&L=1; http://www.thieme-connect.de/DOI/DOI?10.1160/TH13-06-0509; https://dx.doi.org/10.1160/th13-06-0509; https://www.thieme-connect.de/products/ejournals/abstract/10.1160/TH13-06-0509
Schattauer GmbH
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