Synthesis and characterization of polymer-(multi)-peptide conjugates for control of specific cell aggregation
Journal of Biomaterials Science, Polymer Edition, ISSN: 1568-5624, Vol: 9, Issue: 3, Page: 207-226
1998
- 32Citations
- 10Captures
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Metrics Details
- Citations32
- Citation Indexes32
- 32
- CrossRef21
- Captures10
- Readers10
- 10
Article Description
A new synthetic approach has been applied to obtain novel di-, tetra-, and (multi)-peptide containing polymer conjugates in quantitative yields with a high degree of conjugation. Bis-(N-hydroxysuccinimidyl) esters of PEG (M= 200, 600, 1400, 2000, and 3400) were synthesized and studied in a condensation reaction with synthetic peptides: glycine-glycine-tyrosine-arginine (GGYR), a model peptide, and glycine-arginine-glycine-aspartic acid-tyrosine (GRGDY), a sequence known to promote cell adhesion and aggregation. Tetra-substituted derivatives of PEG-based conjugates were synthesized by coupling L-aspartic acid and L-aspartyl-L-phenylalanine through a condensation procedure in organic media. Poly(acrylic acid) and co-polymers (M= 2000 and 5000) were studied as a model of multifunctional linear polymers in the reaction with L-tryptophan and GGYR. Alternative polymer-(multi)-peptide conjugates were successfully synthesized using Starburst® dendrimer PAMAM (G = 3), ’short’ and ’long’-chain PEG-based active esters and GRGDY. The structure of the intermediate precursors and peptide-conjugates was confirmed by spectral (UV-Vis, FTIRH-NMR) and chromatographic (RP-HPLC and SEC) methods. By varying the properties of the interconnecting polymer - such as hydrophobicity, molecular weight, and functionality - a set of polymer-GRGDY conjugates was synthesized. © VSP 1998.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031890618&origin=inward; http://dx.doi.org/10.1163/156856298x00613; http://www.ncbi.nlm.nih.gov/pubmed/9556758; https://www.tandfonline.com/doi/full/10.1163/156856298X00613; http://www.tandfonline.com/doi/abs/10.1163/156856298X00613; http://www.ingentaconnect.com/content/vsp/bsp/1998/00000009/00000003/art00002
Informa UK Limited
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