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Targeted Anti-Hepatocellular Carcinoma Research of Targeted Peptides Combined with Drug-Loaded Cell-Derived Microparticles

Journal of biomedical nanotechnology, ISSN: 1550-7033, Vol: 18, Issue: 4, Page: 1009-1018
2022
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Article Description

To conduct an anti-tumor research by using targeted drug-loaded cell-derived microparticles to target the tumor microenvironment and enhance NK cell killing function. In this experiment, we obtained HepG2 tumor cell-derived microparticles by physical extrusion, high speed centrifugation and filtration, modified the hepatocellular carcinoma targeting peptide SP94 on the surface of microparticles and encapsulated the TGF-β inhibitor SB505124. Finally we validated and analyzed whether the new drug delivery system can target to tumor site and enhance the anti-tumor function of NK cells. This type of novel targeted cell-derived microparticles drug delivery system will provide a novel idea for tumor immunotherapy.

Bibliographic Details

Ximei, Xu; Yiqun, Luo; Zhikun, Zhang; Yueli, Nie; Xiuli, Liu; Wei, Shi; Tao, Wu; Pan, Wu; Xiyu, Liu; Yong, Huang; Yongxiang, Zhao; Lu, Gan; Liping, Zhong; Qiaoying, Chen; Jian, He

American Scientific Publishers

Medicine

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