Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels
Journal of Clinical Investigation, ISSN: 0021-9738, Vol: 108, Issue: 9, Page: 1315-1320
2001
- 241Citations
- 66Captures
- 2Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations241
- Citation Indexes240
- 240
- CrossRef209
- Policy Citations1
- Policy Citation1
- Captures66
- Readers66
- 53
- 13
- Mentions2
- News Mentions2
- News2
Most Recent News
Screening of House Dust from Chinese Homes for Chemicals with Liver X Receptors Binding Activities and Characterization of Atherosclerotic Activity Using an in Vitro Macrophage Cell Line and ApoE−/− Mice
Introduction The incidence of cardiovascular disease (CVD) has increased in many countries, and CVD has been the leading underlying cause of death worldwide since 2000
Article Description
Excess accumulation of cholesterol in macrophages results in foam cell production and lesion development. Recent studies have demonstrated that ATP-binding cassette protein A1 (ABCA1) is highly regulated in macrophages and mediates the efflux of cholesterol and phospholipids to apolipoproteins, a process necessary for HDL formation. The goal of this study was to determine the contribution of monocyte/macrophage ABCA1 to HDL formation in vivo. We generated mice expressing ABCA1 in macrophages and mice with selected inactivation of ABCA1 in macrophages by bone marrow transplantation in ABCA1-deficient (ABC1) and wild-type (WT) mice. At all times, the level of HDL in ABC1 recipient mice remained low relative to WT recipient mice irrespective of the genotype of the donor macrophage ABCA1 or high-fat feeding. Expression of WT macrophage ABCA1 in ABC1 mice resulted in a small but significant increase in apoA,-I levels starting 2 weeks after transplantation. No further increase in apoAI was observed up to 14 weeks after transplantation. The increase in apoAI was accompanied by a small but significant increase in HDL cholesterol 6 weeks after transplantation. The HDL formed as a consequence of the expression of WT macrophage ABCA1 migrated to the alpha position in a two-dimensional gel electrophoresis. These results demonstrate that monocyte/macrophage ABCA1 contributes to HDL formation; however, the contribution to the overall plasma HDL levels is minimal.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035191911&origin=inward; http://dx.doi.org/10.1172/jci200112810; http://dx.doi.org/10.1172/jci12810; http://www.ncbi.nlm.nih.gov/pubmed/11696576; http://www.jci.org/articles/view/12810; https://dx.doi.org/10.1172/jci12810; https://www.jci.org/articles/view/12810; https://dx.doi.org/10.1172/jci200112810
American Society for Clinical Investigation
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