Disruption of the Ang II type 1 receptor promotes longevity in mice
Journal of Clinical Investigation, ISSN: 0021-9738, Vol: 119, Issue: 3, Page: 524-530
2009
- 430Citations
- 184Captures
- 2Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations430
- Citation Indexes430
- 430
- CrossRef393
- Captures184
- Readers184
- 184
- Mentions2
- Blog Mentions1
- Blog1
- References1
- Wikipedia1
Article Description
The renin-angiotensin system plays a role in the etiology of hypertension and the pathophysiology of cardiac and renal diseases in humans. Ang II is the central product of this system and is involved in regulating immune responses, inflammation, cell growth, and proliferation by acting through Ang II type 1 receptors (AT1 and AT2). Here, we show that targeted disruption of the Agtr1a gene that encodes AT1A results in marked prolongation of life span in mice. Agtr1a-/- mice developed less cardiac and vascular injury, and multiple organs from these mice displayed less oxidative damage than wild-type mice. The longevity phenotype was associated with an increased number of mitochondria and upregulation of the prosurvival genes nicotinamide phosphoribosyltransferase (Nampt) and sirtuin 3 (Sirt3) in the kidney. In cultured tubular epithelial cells, Ang II downregulated Sirt3 mRNA, and this effect was inhibited by an AT1 antagonist. These results demonstrate that disruption of AT1 promotes longevity in mice, possibly through the attenuation of oxidative stress and overexpression of prosurvival genes, and suggests that the Ang II/AT1 pathway may be targeted to influence life span in mammals.
Bibliographic Details
10.1172/jci36703; 10.3410/f.1158328.619046; 10.3410/f.1158328.620569; 10.3410/f.1158328.618472; 10.3410/f.1158328.2806069; 10.3410/f.1158328.620829; 10.3410/f.1158328.628782
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=65349128571&origin=inward; http://dx.doi.org/10.1172/jci36703; http://www.ncbi.nlm.nih.gov/pubmed/19197138; https://facultyopinions.com/prime/1158328#eval619046; http://dx.doi.org/10.3410/f.1158328.619046; https://facultyopinions.com/prime/1158328#eval620569; http://dx.doi.org/10.3410/f.1158328.620569; http://www.jci.org/articles/view/36703; https://facultyopinions.com/prime/1158328#eval618472; http://dx.doi.org/10.3410/f.1158328.618472; https://facultyopinions.com/prime/1158328#eval2806069; http://dx.doi.org/10.3410/f.1158328.2806069; https://facultyopinions.com/prime/1158328#eval620829; http://dx.doi.org/10.3410/f.1158328.620829; https://facultyopinions.com/prime/1158328#eval628782; http://dx.doi.org/10.3410/f.1158328.628782; https://dx.doi.org/10.1172/jci36703; https://www.jci.org/articles/view/36703; http://www.jci.org/articles/view/36703/files/pdf; http://f1000.com/1158328#eval2806069; http://f1000.com/1158328#eval618472; http://f1000.com/1158328#eval620569; http://f1000.com/1158328#eval619046; http://f1000.com/1158328#eval620829; http://europepmc.org/abstract/med/19197138; http://europepmc.org/articles/PMC2648681; http://f1000.com/1158328#eval628782
Faculty Opinions Ltd
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know