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Virulence determinants of pandemic influenza viruses

Journal of Clinical Investigation, ISSN: 0021-9738, Vol: 121, Issue: 1, Page: 6-13
2011
  • 167
    Citations
  • 0
    Usage
  • 210
    Captures
  • 3
    Mentions
  • 38
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    167
  • Captures
    210
  • Mentions
    3
    • News Mentions
      2
      • News
        2
    • References
      1
      • Wikipedia
        1
  • Social Media
    38
    • Shares, Likes & Comments
      38
      • Facebook
        38

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Article Description

Influenza A viruses cause recurrent, seasonal epidemics and occasional global pandemics with devastating levels of morbidity and mortality. The ability of influenza A viruses to adapt to various hosts and undergo reassortment events ensures constant generation of new strains with unpredictable degrees of pathogenicity, transmissibility, and pandemic potential. Currently, the combination of factors that drives the emergence of pandemic influenza is unclear, making it impossible to foresee the details of a future outbreak. Identification and characterization of influenza A virus virulence determinants may provide insight into genotypic signatures of pathogenicity as well as a more thorough understanding of the factors that give rise to pandemics.

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