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High long-term test–retest reliability for extrastriatal C-raclopride binding in healthy older adults

Journal of Cerebral Blood Flow and Metabolism, ISSN: 1559-7016, Vol: 40, Issue: 9, Page: 1859-1868
2020
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Article Description

In vivo dopamine D2-receptor availability is frequently assessed with C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal C-raclopride binding potential (BP) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test–retest reliability in a sample of younger adults. The present work demonstrates high seven-month test–retest reliability of striatal and extrastriatal C-raclopride BP values in healthy, older adults (n = 27, age: 64–78 years). Mean C-raclopride BP values were stable between test sessions in subcortical nuclei, and in frontal and temporal cortices (p > 0.05). Across all structures analyzed, intraclass correlation coefficients were high (0.85–0.96), absolute variability was low (mean: 4–8%), and coefficients of variance ranged between 9 and 25%. Furthermore, regional C-raclopride BP values correlated with previously determined F-fallypride BP values (ρ = 0.97 and 0.92 in correlations with and without striatal values, respectively, p < 0.01) and postmortem determined D2-receptor densities (including striatum: ρ = 0.92; p < 0.001; excluding striatum: ρ = 0.75; p = 0.067). These observations suggest that extrastriatal C-raclopride measurements represent a true D2 signal.

Bibliographic Details

Karalija, Nina; Jonassson, Lars; Johansson, Jarkko; Papenberg, Goran; Salami, Alireza; Andersson, Micael; Riklund, Katrine; Nyberg, Lars; Boraxbekk, Carl-Johan

SAGE Publications

Neuroscience; Medicine

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