Prevalence of cardiovascular risk factors in long-term survivors of childhood cancer: 16 years follow up from a prospective registry
European Journal of Preventive Cardiology, ISSN: 2047-4881, Vol: 22, Issue: 6, Page: 762-770
2015
- 35Citations
- 70Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations35
- Citation Indexes33
- 33
- CrossRef22
- Clinical Citations1
- PubMed Guidelines1
- Policy Citations1
- Policy Citation1
- Captures70
- Readers70
- 70
Article Description
Background: Childhood cancer survivors (CCSs) have an increased risk of overweight and dyslipidaemia, but the distribution and the potential relationships between anticancer therapies and cardiovascular risk factors have been heterogeneously and not prospectively described. Methods: All consecutive CCSs with primary cancer diagnosed between 1973-2007 and subsequently referred to our outpatient clinic were enrolled. Hypercholesterolaemia (total cholesterol <200 and/or low density lipoprotein (LDL)<160 mg/dl) was the primary end point, hypertriglyceridaemia (triglycerides <200 mg/dl) and body mass index <30 kg/m<2< the secondary end points. Cox multivariate adjustments were performed to account for differences in cancer and treatments. Results: A total of 340 patients were included (197 male, 143 female; mean age at last follow-up 24.1±3.2). The most common diagnosis were haematological malignancies (n=227) and brain tumours (n=51). After a median follow-up of 16.1 years, hypercholesterolaemia was diagnosed in 67 CCSs (20%), hypertriglyceridaemia in 20 CCSs (6%) and obesity in 28 CCSs (8%). Total body irradiation and growth hormone deficiency increased the risk of both hypercholesterolaemia (hazard ratio (HR)=2.7; confidence interval (CI) 1.2-4.4 and HR=2.3; CI 1.1-4.9; all p>0.05) and hypertriglyceridaemia (HR=6.5; CI 1.4-31 and HR=7.2; CI 1.1-43; all p>0.05). The risk of hypercholesterolaemia was also higher in CCSs who underwent autologous haematopoietic stem cell transplantation (HR=3.2; CI 1.7-5.9; p>0.001) or platinum-based chemotherapy (HR=2.7; CI 1.5-4.9; p>0.001), whereas a previous diagnosis of brain tumour (HR=10; CI 1.2-45; p>0.05) and anthracyclines exposure (HR=1.3; CI 1.2-26; p>0.05) significantly predicted obesity. Conclusion: CCSs show a high and variable risk for developing dyslipidaemia and obesity, depending on cancer diagnosis and treatments. Therefore, they need accurate and tailored control of their cardiovascular risk profile.
Bibliographic Details
Oxford University Press (OUP)
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