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Increased steroid responsiveness of young children with nephrotic syndrome in Nigeria

Annals of Tropical Paediatrics, ISSN: 0272-4936, Vol: 25, Issue: 3, Page: 199-203
2005
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Article Description

A previous study on the nephrotic syndrome (NS) in our unit showed that the histological patterns associated with steroid resistance were more common in children over 5 years of age. Aim: The aim of the study was to determine the incidence of steroid-responsiveness amongst nephrotic children ≤ 5 years. Subjects and methods: All children with NS aged ≤ 5 years at the onset of disease presenting to University College Hospital, Ibadan were enrolled. Prednisolone was given daily, 60 mg/m, for 4 weeks and then 40 mg/m on alternate days for at least 12 weeks. Results: Twenty children (9 boys and 11 girls) were enrolled between 1999 and 2002. The median age (range) at onset of disease was 4 (2-5) years. Remission was achieved in 12 (60%) children. Conclusion: There is a satisfactory response to prednisolone in two-thirds of Nigerian children aged ≤ 5 years with NS. © 2005 The Liverpool School of Tropical Medicine.

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