Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro–aged or –injured mouse platelets
Blood, ISSN: 0006-4971, Vol: 102, Issue: 12, Page: 4229-4235
2003
- 153Citations
- 64Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations153
- Citation Indexes152
- 152
- CrossRef138
- Patent Family Citations1
- Patent Families1
- Captures64
- Readers64
- 64
Article Description
Platelet transfusions are a crucial component of support for patients with severe thrombocytopenia. Storage of platelet concentrates, however, is associated with a reduction in platelet posttransfusion recovery and hemostatic function. In this study, we established a model of mitochondrial injury that resembles platelet storage lesion. Mitochondrial injury, provoked by incubation of platelets with carbonyl cyanide m-chlorophenylhydrazone (CCCP), led to reduced posttransfusion recovery in mice, an effect that directly correlated with the duration of treatment. Damaged platelets were characterized by shape change, disruption of membrane asymmetry, surface expression of P-selectin, and profound proteolysis of GPIbα. Using our model, we identified a key role for endogenous metalloproteinase(s) in platelet clearance, as their inhibition markedly improved posttransfusion recovery of both the mitochondria-injured and in vitro-aged mouse platelets. Metalloproteinase inhibition also prevented proteolysis of GPIbα on damaged platelets, thereby improving the hemostatic function of these cells in vivo. We propose that inhibition of metalloproteinase activity during storage could significantly improve the effectiveness of platelet transfusions. Surface expression of GPIbα might be a powerful marker to determine the quality of platelet concentrates, because it reflects metalloproteinase activity in vitro. (Blood. 2003;102: 4229-4235)
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006497120440388; http://dx.doi.org/10.1182/blood-2003-04-1305; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0345688868&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12907434; https://ashpublications.org/blood/article/102/12/4229/16751/Metalloproteinase-inhibitors-improve-the-recovery; https://dx.doi.org/10.1182/blood-2003-04-1305
American Society of Hematology
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