IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease
Blood, ISSN: 0006-4971, Vol: 106, Issue: 7, Page: 2433-2435
2005
- 42Citations
- 24Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations42
- Citation Indexes42
- 42
- CrossRef37
- Captures24
- Readers24
- 24
Article Description
Interleukin-2 (IL-2) and IL-15 are structurally related cytokines that share receptor components but display markedly different effects in multiple in vivo model systems. Here we demonstrate that IL-15 but not IL-2 exacerbates xenogeneic graft-versus-host disease (X-GVHD) in severe combined immunodeficient murine recipients of human peripheral-blood lymphocytes (hu-PBL-SCID). Treatment of hu-PBL-SCID mice with IL-15 resulted in rapid fatality, lymphocytic infiltrations in the liver, lung, and spleen consistent with X-GVHD, and a marked expansion of human CD4 + and CD8 + T cells compared with controls. Depletion of human T cells in vivo abrogated the lethality of IL-15 treatment. To our knowledge, these data are the first to demonstrate in vivo activation and expansion of human T lymphocytes in response to IL-15 with concomitant exacerbation of human T-cell-mediated X-GVHD. (Blood. 2005;106:2433-2435)
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006497120672378; http://dx.doi.org/10.1182/blood-2005-04-1597; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=27144538077&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15976176; https://ashpublications.org/blood/article/106/7/2433/21678/IL15-but-not-IL2-rapidly-induces-lethal-xenogeneic; https://dx.doi.org/10.1182/blood-2005-04-1597; https://ashpublications.org/blood/article/106/7/2433/21678/IL-15-but-not-IL-2-rapidly-induces-lethal
American Society of Hematology
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