Hematopoietic stem cell function requires 12/15-lipoxygenase–dependent fatty acid metabolism
Blood, ISSN: 0006-4971, Vol: 115, Issue: 24, Page: 5012-5022
2010
- 52Citations
- 69Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations52
- Citation Indexes52
- 52
- CrossRef43
- Captures69
- Readers69
- 69
Article Description
Fatty acid metabolism governs multiple intracellular signaling pathways in many cell types, but its role in hematopoietic stem cells (HSCs) is largely unknown. Herein, we establish a critical role for 12/15-lipoxygenase (12/15-LOX)–mediated unsaturated fatty acid metabolism in HSC function. HSCs from 12/15-LOX–deficient mice are severely compromised in their capacity to reconstitute the hematopoietic compartment in competitive and serial reconstitution assays. Furthermore, we demonstrate that 12/15-LOX is required for the maintenance of long-term HSC quiescence and number. The defect in HSCs is cell-autonomous and associated with a selective reduction in 12/15-LOX–mediated generation of bioactive lipid mediators and reactive oxygen species and with a decrease in canonical Wnt signaling as measured by nuclear β-catenin staining. These results have implications for development, aging, and transformation of the hematopoietic compartment.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006497120348576; http://dx.doi.org/10.1182/blood-2009-09-243139; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77954666269&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20357242; https://ashpublications.org/blood/article/115/24/5012/27205/Hematopoietic-stem-cell-function-requires
American Society of Hematology
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