Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs
Blood, ISSN: 0006-4971, Vol: 116, Issue: 18, Page: 3456-3464
2010
- 79Citations
- 64Captures
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Metrics Details
- Citations79
- Citation Indexes79
- 79
- CrossRef78
- Captures64
- Readers64
- 64
Article Description
Secondary lymphoid organs provide a unique microenvironment for generation of immune responses. Using a cell type–specific conditional knockout approach, we have dissected contributions of tumor necrosis factor (TNF) produced by B cells (B-TNF) or T cells (T-TNF) to the genesis and homeostatic organization of secondary lymphoid organs. In spleen, lymph nodes and Peyer patches, the cellular source of TNF, and its molecular form (soluble versus membrane-bound) appeared distinct. In spleen, in addition to major B-TNF signal, a complementary T-TNF signal contributed to the microstructure. In contrast, B-TNF predominantly controlled the development of follicular dendritic cells and B-cell follicles in Peyer patches. In lymph nodes, cooperation between TNF expressed by B and T cells was necessary for the maintenance of microarchitecture and for generation of an efficient humoral immune response. Unexpectedly, soluble but not membrane TNF expressed by B cells was essential for the organization of the secondary lymphoid organs. Thus, the maintenance of each type of secondary lymphoid organ is orchestrated by distinct contributions of membrane-bound and soluble TNF produced by B and T lymphocytes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006497120311423; http://dx.doi.org/10.1182/blood-2009-10-249177; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78149329150&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20634375; https://ashpublications.org/blood/article/116/18/3456/27957/Cellular-source-and-molecular-form-of-TNF-specify; https://dx.doi.org/10.1182/blood-2009-10-249177
American Society of Hematology
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