CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin
Blood, ISSN: 0006-4971, Vol: 118, Issue: 15, Page: 4265-4273
2011
- 80Citations
- 115Captures
- 4Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations80
- Citation Indexes80
- 80
- CrossRef69
- Captures115
- Readers115
- 115
- Mentions4
- References4
- 4
Article Description
The activation of endothelial cells is critical to initiating an inflammatory response. Activation induces the fusion of Weibel-Palade Bodies (WPB) with the plasma membrane, thus transferring P-selectin and VWF to the cell surface, where they act in the recruitment of leukocytes and platelets, respectively. CD63 has long been an established component of WPB, but the functional significance of its presence within an organelle that acts in inflammation and hemostasis was unknown. We find that ablating CD63 expression leads to a loss of P-selectin–dependent function: CD63-deficient HUVECs fail to recruit leukocytes, CD63-deficient mice exhibit a significant reduction in both leukocyte rolling and recruitment and we show a failure of leukocyte extravasation in a peritonitis model. Loss of CD63 has a similar phenotype to loss of P-selectin itself, thus CD63 is an essential cofactor to P-selectin.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006497120410729; http://dx.doi.org/10.1182/blood-2010-11-321489; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80054096264&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/21803846; https://ashpublications.org/blood/article/118/15/4265/29073/CD63-is-an-essential-cofactor-to-leukocyte; https://dx.doi.org/10.1182/blood-2010-11-321489
American Society of Hematology
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