Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates
Blood, ISSN: 0006-4971, Vol: 122, Issue: 15, Page: 2582-2590
2013
- 25Citations
- 31Captures
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Metrics Details
- Citations25
- Citation Indexes25
- 25
- CrossRef24
- Captures31
- Readers31
- 31
Article Description
Previously, we detected B cells expressing receptors for blood group A carbohydrates in the CD11b + CD5 + B-1a subpopulation in mice, similar to that in blood group O or B in humans. In the present study, we demonstrate that CD1d-restricted natural killer T (NKT) cells are required to produce anti-A antibodies (Abs), probably through collaboration with B-1a cells. After immunization of wild-type (WT) mice with human blood group A red blood cells (A-RBCs), interleukin (IL)-5 exclusively and transiently increased and the anti-A Abs were elevated in sera. However, these reactions were not observed in CD1d −/− mice, which lack NKT cells. Administration of anti-mouse CD1d blocking monoclonal Abs (mAb) prior to immunization abolished IL-5 production by NKT cells and anti-A Ab production in WT mice. Administration of anti-IL-5 neutralizing mAb also diminished anti-A Ab production in WT mice, suggesting that IL-5 secreted from NKT cells critically regulates anti-A Ab production by B-1a cells. In nonobese diabetic/severe combined immunodeficient (NOD/SCID/γ c null ) mice, into which peripheral blood mononuclear cells from type O human volunteers were engrafted, administration of anti-human CD1d mAb prior to A-RBC immunization completely inhibited anti-A Ab production. Thus, anti-CD1d treatment might constitute a novel approach that could help in evading Ab-mediated rejection in ABO-incompatible transplant recipients.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006497120497678; http://dx.doi.org/10.1182/blood-2012-02-407452; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84888224690&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/23943651; https://ashpublications.org/blood/article/122/15/2582/31923/Blockade-of-invariant-TCRCD1d-interaction
American Society of Hematology
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