HGAL localization to cell membrane regulates B-cell receptor signaling
Blood, ISSN: 0006-4971, Vol: 125, Issue: 4, Page: 649-657
2015
- 19Citations
- 29Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations19
- Citation Indexes19
- 19
- CrossRef5
- Captures29
- Readers29
- 29
Article Description
Human germinal center–associated lymphoma (HGAL) is specifically expressed only in germinal center (GC) B lymphocytes and GC-derived lymphomas. HGAL protein decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. HGAL protein also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors. Herein we demonstrate that HGAL protein can be myristoylated and palmitoylated and that these modifications localize HGAL to cellular membrane raft microdomains with distinct consequences for BCR signaling and chemoattractant-induced cell mobility. In BCR signaling, raft localization of HGAL facilitates interaction with Syk and modulation of the BCR activation and signaling, which induces HGAL phosphorylation and redistribution from lipid raft to bulk membrane and cytoplasm, followed by degradation. In contrast, HGAL myristoylation and palmitoylation avert its inhibitory effects on chemoattractant-induced cell motility. These findings further elucidate the growing and complex role of HGAL in B-cell biology and suggest that membrane-bound and cytoplasmic HGAL protein differently regulates distinct biological processes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006497120395057; http://dx.doi.org/10.1182/blood-2014-04-571331; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84921502858&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/25381061; https://ashpublications.org/blood/article/125/4/649/33867/HGAL-localization-to-cell-membrane-regulates-Bcell; http://www.bloodjournal.org/lookup/doi/10.1182/blood-2014-04-571331; http://www.bloodjournal.org/content/125/4/649; http://www.bloodjournal.org/content/125/4/649.abstract; http://www.bloodjournal.org/content/125/4/649.full.pdf; https://ashpublications.org/blood/article-pdf/125/4/649/1386944/649.pdf; http://www.bloodjournal.org/lookup/doi/10.1182/blood-2014-04-571331?sso-checked=true; http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-04-571331; http://www.bloodjournal.org/content/125/4/649?sso-checked=true; https://signin.hematology.org/Login.aspx?vi=9&vt=a0f882b903d54d4f0627fd199849a93c6a373903a71282dec040ebb80f4def73c8388dba5de7dbc120d26d53f869233bce7f0177b43f4fffc6a05db1ca2b2fb0f0aafd52068e31f57ed25433fc77e87b0e98320b7e14461a3d9865daadf5840f0312a23567ff7ffad582d80eb1077f23&DPLF=Y
American Society of Hematology
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know