Emerging anticoagulant strategies
Blood, ISSN: 0006-4971, Vol: 129, Issue: 2, Page: 147-154
2017
- 67Citations
- 129Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations67
- Citation Indexes67
- 67
- CrossRef25
- Captures129
- Readers129
- 129
- Mentions1
- References1
- Wikipedia1
Article Description
Despite the introduction of direct oral anticoagulants (DOACs), the search for more effective and safer antithrombotic strategies continues. Better understanding of the pathogenesis of thrombosis has fostered 2 new approaches to achieving this goal. First, evidence that thrombin may be as important as platelets to thrombosis at sites of arterial injury and that platelets contribute to venous thrombosis has prompted trials comparing anticoagulants with aspirin for secondary prevention in arterial thrombosis and aspirin with anticoagulants for primary and secondary prevention of venous thrombosis. These studies will help identify novel treatment strategies. Second, emerging data that naturally occurring polyphosphates activate the contact system and that this system is critical for thrombus stabilization and growth have identified factor XII (FXII) and FXI as targets for new anticoagulants that may be even safer than the DOACs. Studies are needed to determine whether FXI or FXII is the better target and to compare the efficacy and safety of these new strategies with current standards of care for the prevention or treatment of thrombosis. Focusing on these advances, this article outlines how treatment strategies for thrombosis are evolving and describes the rationale and approaches to targeting FXII and FXI. These emerging anticoagulant strategies should address unmet needs and reduce the systemic underuse of anticoagulation because of the fear of bleeding.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006497120337964; http://dx.doi.org/10.1182/blood-2016-09-692996; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85016259692&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/27780803; https://ashpublications.org/blood/article/129/2/147/36070/Emerging-anticoagulant-strategies; https://dx.doi.org/10.1182/blood-2016-09-692996
American Society of Hematology
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