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The effect of text messaging on latent tuberculosis treatment adherence: A randomised controlled trial

European Respiratory Journal, ISSN: 1399-3003, Vol: 51, Issue: 2
2018
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Article Description

There is limited high-quality evidence available to inform the use of text messaging to improve latent tuberculosis infection (LTBI) treatment adherence. We performed a parallel, randomised controlled trial at two sites to assess the effect of a two-way short message service on LTBI adherence. We enrolled adults initiating LTBI therapy from June 2012 to September 2015 in British Columbia, Canada. Participants were randomised in a 1:1 ratio to standard LTBI treatment (control) or standard LTBI treatment plus two-way weekly text messaging (intervention). The primary outcome was treatment completion, defined as taking 80% prescribed doses within 12 months (isoniazid) or 6 months (rifampin) of enrolment. The trial was unblinded except for the data analyst. A total of 358 participants were assigned to the intervention (n=170) and control (n=188) arms. In intention-to-treat analysis, the proportion of participants completing LTBI therapy in the intervention and control arms was 79.4% and 81.9%, respectively (RR 0.97, 95% CI 0.88–1.07; p=0.550). Results were similar for pre-specified secondary end-points, including time-to-completion of LTBI therapy, completion of >90% of prescribed LTBI doses and health-related quality of life. Weekly two-way text messaging did not improve LTBI completion rates compared to standard LTBI care; however, completion rates were high in both treatment arms.

Bibliographic Details

Johnston, James C; van der Kop, Mia L; Smillie, Kirsten; Ogilvie, Gina; Marra, Fawziah; Sadatsafavi, Mohsen; Romanowski, Kamila; Budd, Matthew A; Hajek, Jan; Cook, Victoria; Lester, Richard T

European Respiratory Society (ERS)

Medicine

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