Decoding the impact of the placebo response in clinical trials for chronic cough
ERJ Open Research, ISSN: 2312-0541, Vol: 10, Issue: 5
2024
- 2Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Review Description
Chronic cough is a prevalent and challenging condition, with limited treatment options available. The interpretation of clinical trial results for antitussive drugs is complicated by the presence of the placebo response, which can confound outcomes and impede regulatory approval. This review aims to explore the impact of the placebo response on clinical trials for cough medications and elucidate the underlying mechanisms involved. The multifaceted nature of antitussive effects, including pharmacological, psychological/neurobiological and nonspecific effects, is discussed. Additionally, potential solutions to address the placebo response in future cough medication development, such as strategic study design, appropriate choice of end-points and meticulous patient selection, are proposed. More progress to harness this issue is urgently needed.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85199491168&origin=inward; http://dx.doi.org/10.1183/23120541.00335-2024; http://www.ncbi.nlm.nih.gov/pubmed/39469270; https://publications.ersnet.org/lookup/doi/10.1183/23120541.00335-2024; https://dx.doi.org/10.1183/23120541.00335-2024; https://publications.ersnet.org/content/erjor/early/2024/05/23/2312054100335-2024
European Respiratory Society (ERS)
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