Local comparison of protein structures highlights cases of convergent evolution in analogous functional sites
BMC Bioinformatics, ISSN: 1471-2105, Vol: 8, Issue: SUPPL. 1, Page: S24
2007
- 17Citations
- 21Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef9
- Captures21
- Readers21
- 21
Article Description
Background: We performed an exhaustive search for local structural similarities in an ensemble of non-redundant protein functional sites. With the purpose of finding new examples of convergent evolution, we selected only those matching sites composed of structural regions whose residue order is inverted in the relative protein sequences. Results: A novel case of local analogy was detected between members of the ABC transporter and of the HprK/P families in their ATP binding site. This case cannot be derived by events of circular permutation since the residues of one of the region pairs are located in reverse order in the sequence of the two protein families. One of the analogous binding sites, the one identified in HprK/P, is known to also bind pyrophosphate, which is used as preferred energy source in its kinase and phosphorylase activity. Conclusion: The discovery of this striking molecular similarity, also associated to a functional similarity, may help in suggesting new experiments aimed at a deeper understanding of members of the ABC transporter family known to be involved in many serious human diseases. © 2007 Ausiello et al; licensee BioMed Central Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34248185418&origin=inward; http://dx.doi.org/10.1186/1471-2105-8-s1-s24; http://www.ncbi.nlm.nih.gov/pubmed/17430569; https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-S1-S24; http://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-S1-S24; https://dx.doi.org/10.1186/1471-2105-8-s1-s24
Springer Nature
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