Claudins play a role in normal and tumor cell motility
BMC Cell Biology, ISSN: 1471-2121, Vol: 14, Issue: 1, Page: 19
2013
- 30Citations
- 54Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations30
- Citation Indexes29
- 29
- CrossRef25
- Policy Citations1
- Policy Citation1
- Captures54
- Readers54
- 54
Article Description
Background: Claudins are key integral proteins of the tight junction. Although they play an essential role in controlling paracellular diffusion in epithelia, increasing evidence supports a role for these proteins in non-barrier forming activities. To elucidate a potential function for claudins outside of their traditional role in tight junctions, subcellular localization of claudin-4 was determined in normal mammary epithelial cells as well as breast and ovarian cancer cell lines and the effects of a claudin mimic peptide on cell motility were determined.Results: Immunofluorescence revealed that claudin-4 was localized along cellular projections. Using a fluorescent peptide that mimics a conserved sequence in the second extracellular loop of a set of claudin subtypes, that includes claudin-4, exposure of this loop to the extracellular environment was confirmed in non-polarized cells. This peptide inhibited cell motility when normal mammary epithelial cells as well as breast and ovarian tumor cells were subjected to a wound healing assay. Knockdown of claudin-4 also inhibited cell motility and the mimic peptide had no effect on motility in the claudin-4 knockdown cells. This effect on motility was seen when cells were grown on collagen, but not when cells were grown on non-physiological cell adhesive or fibronectin.Conclusion: The second extracellular loop of claudins is able to interact with the extracellular environment to promote normal and tumor cell motility when it is not associated with tight junction structures. © 2013 Webb et al.; licensee BioMed Central Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875151252&origin=inward; http://dx.doi.org/10.1186/1471-2121-14-19; http://www.ncbi.nlm.nih.gov/pubmed/23521713; https://bmcmolcellbiol.biomedcentral.com/articles/10.1186/1471-2121-14-19; https://dx.doi.org/10.1186/1471-2121-14-19; http://bmccellbiol.biomedcentral.com/articles/10.1186/1471-2121-14-19; https://bmcmolcellbiol.biomedcentral.com/counter/pdf/10.1186/1471-2121-14-19; http://www.biomedcentral.com/1471-2121/14/19
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