Serum TGF-β1 and SMAD3 levels are closely associated with coronary artery disease
BMC Cardiovascular Disorders, ISSN: 1471-2261, Vol: 14, Issue: 1, Page: 18
2014
- 37Citations
- 37Captures
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Metrics Details
- Citations37
- Citation Indexes37
- 37
- CrossRef22
- Captures37
- Readers37
- 37
Article Description
Background: Coronary artery disease (CAD) is one of the most common diseases leading to mortality and morbidity worldwide. There is considerable debate on whether serum transforming growth factor β1 (TGF-β1) levels are associated with long-term major adverse cardiovascular events in patients with CAD, and to date, no study has specifically addressed levels in patients with different degrees of CAD severity.Methods: Serum TGF-β1 and mothers against decapentaplegic homolog 3 (SMAD3) concentrations were evaluated in 279 patients with CAD and 268 controls without CAD. The clinical and biochemical characteristics of all subjects were also determined and analyzed.Results: TGF-β1 and SMAD3 concentrations in CAD patients were significantly higher than those in the controls. The serum TGF-β1 level in acute myocardial infarction (AMI) was significantly higher than that in both stable angina pectoris (SAP) and unstable angina pectoris (UAP) (p < 0.05), while there was no marked difference between levels in SAP and UAP (p > 0.05). SMAD3 levels showed no obvious difference among AMI, SAP, and UAP. TGF-β1 and SMAD3 are potential biomarkers for CAD, and may be more accurate than Lpa, ApoA1, uric acid, BUN, or triglycerides (TG).Conclusions: Serum TGF-β1 and SMAD3 levels are closely associated with CAD, and may become useful biomarkers for diagnosis and risk stratification. © 2014 Chen et al.; licensee BioMed Central Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896391176&origin=inward; http://dx.doi.org/10.1186/1471-2261-14-18; http://www.ncbi.nlm.nih.gov/pubmed/24533640; https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-14-18; https://dx.doi.org/10.1186/1471-2261-14-18
Springer Science and Business Media LLC
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