Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: A state of the science review
BMC Dermatology, ISSN: 1471-5945, Vol: 11, Issue: 1, Page: 13
2011
- 64Citations
- 59Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations64
- Citation Indexes63
- 63
- CrossRef60
- Policy Citations1
- 1
- Captures59
- Readers59
- 59
Article Description
Background: Paget's disease is a rare skin disorder occurring in the breast (mammary) or in the groin, genital, peri-anal and axillary regions (extra-mammary). Typical treatment involves surgical excision, which in the case of extra-mammary Paget's disease, can lead to significant morbidity. Photodynamic therapy (PDT) which uses a topical or intravenous photosensitizing agent that is activated by a light source to ablate abnormal tissue, offers a minimally invasive alternative. The purpose of this study was to assess the effectiveness of photodynamic therapy in the treatment of Paget's disease.Methods: Following Cochrane guidelines, a comprehensive systematic review of all clinical studies and reports examining the use of PDT for mammary and extra-mammary Paget's disease was conducted. Study quality was assessed using the Oxford Levels of Evidence Scale.Results: 21 retrospective and 2 prospective non-comparative studies were identified and included in the review: 9 case reports with 1-2 patients and 14 case series with 1-16 patients. These reports totalled 99 patients with 133 extra-mammary Paget's lesions and 3 patients (with 3 lesions) with mammary Paget's disease. Follow-up periods were typically one year or less, with 77/133 extra-mammary lesions exhibiting complete response to PDT. One recurrent mammary skin lesion and two mammary lesions treated concomitantly with surgery also exhibited complete responses.Conclusions: Evidence of the effectiveness of PDT for Paget's disease is promising, but limited. This may, in part, be explained by the rarity of the condition, making controlled comparative clinical trials challenging. © 2011 Nardelli et al; licensee BioMed Central Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79958773346&origin=inward; http://dx.doi.org/10.1186/1471-5945-11-13; http://www.ncbi.nlm.nih.gov/pubmed/21676258; http://bmcdermatol.biomedcentral.com/articles/10.1186/1471-5945-11-13; https://dx.doi.org/10.1186/1471-5945-11-13; https://bmcdermatol.biomedcentral.com/articles/10.1186/1471-5945-11-13
Springer Science and Business Media LLC
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