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Expression of ALDH1 in breast invasive ductal carcinoma: An independent predictor of early tumor relapse

Cancer Cell International, ISSN: 1475-2867, Vol: 13, Issue: 1, Page: 60
2013
  • 33
    Citations
  • 0
    Usage
  • 28
    Captures
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    Mentions
  • 253
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    33
  • Captures
    28
  • Social Media
    253
    • Shares, Likes & Comments
      253
      • Facebook
        253

Article Description

Background: The specific mechanism underlying the contribution of the Aldehyde dehydrogenase 1 (ALDH1) phenotype to metastatic behavior and early tumor relapse in breast cancer is currently unclear.Methods: 147 randomly selected invasive ductal carcinoma samples were assayed for expression of ALDH1A1, NOTCH1, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2), and association of the ALDH1A1 phenotype with clinic pathological features was further evaluated.Results: ALDH1A1-positive cells were detected in 63.3% (93 of 147) of tumors. 80.0% (32 of 40) of tumors with strong ALDH1A1 staining displayed early recurrence, compared with 20.0% (8 of 40) of tumors negative for ALDH1A1 expression (P = 0.027). ALDH1A1 status was significantly correlated with strong malignant proliferative marker Ki67 staining (P = 0.001), and no significantly different expression of ALDH1A1 across the subtypes of ER, PR, and HER2 expression and triple negative features of tumor tissue. Multivariate regression analysis demonstrated that elevated ALDH1A1 expression is an independent predictor of recurrence-free survival and distant metastasis-free survival. Notably, breast cancer tissue strong for ALDH1A1 expression displayed weak NOTCH1 staining compared to ALDH1A1 weak tumor tissue (P = 0.002), and the relationship between ALDH1A1 and NOTCH1 mRNA positivity was significant (Pearson correlation - 0.337, P = 0.014; Spearman's rho - 0.376, P = 0.006). Elevated NOTCH1 mRNA level (using a cut-off value based on the median ALDH1A1 2 value) was associated with reduction of ALDH1A1 mRNA level (P = 0.001).Conclusions: The ALDH1A1 phenotype is an independent predictor of early tumor relapse characteristic (specifically, incidence of early local recurrence and distant metastasis) of invasive ductal carcinoma. The NOTCH1 signaling pathway is possibly involved in the negative association of the ALDH1A1 phenotype with early malignant relapse in invasive ductal carcinoma. © 2013 Zhong et al.; licensee BioMed Central Ltd.

Bibliographic Details

Zhong, Ying; Lin, Yan; Shen, Songjie; Zhou, Yidong; Mao, Feng; Guan, Jinghong; Sun, Qiang

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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