Fine specificity of anti-MSP1 antibodies and multiplicity of plasmodium falciparum merozoite surface protein 1 types in individuals in Nigeria with sub-microscopic infection
Malaria Journal, ISSN: 1475-2875, Vol: 9, Issue: 1, Page: 287
2010
- 8Citations
- 60Captures
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef5
- Captures60
- Readers60
- 60
Article Description
Background: The absence of antibodies specific for the 19 kDa C-terminal domain of merozoite surface protein 1 (MSP1) has been associated with high-density malaria parasitaemia in African populations. The hypothesis that a high prevalence and/or level of anti-MSP1antibodies that may inhibit erythrocyte invasion would be present in apparently healthy individuals who harbour a sub-microscopic malaria infection was tested in this study. Methods: Plasma samples were collected from residents in a region in Nigeria hyperendemic for malaria, who had no detectable parasitaemia by microscopy. Using a competition-based enzyme-linked-immunosorbent assay with two invasion-inhibitory monoclonal antibodies (mAbs) 12.10 and 12.8, the levels and prevalence of specific antibodies were measured. The minimum multiplicity of infection was determined using PCR. The prevalence of anaemia was also measured. Results: Plasma samples from 85% of individuals contained antibodies that bound to MSP1. The inhibition of mAb 12.10 binding was strongly correlated with the prevalence (Spearman correlation test, p < 0.0001) and mean titre of anti-MSP1antibodies (Spearman correlation test, p < 0.001) in the samples. Comparing samples from individuals with multiple infection (group M) and single infection (Group S), group M contained a higher (p = 0.04) prevalence of anti-MSP1antibodies that competed with mAb 12.10. Using a logistic regression model, it was found that the presence of antibodies competitive with mAb 12.10 was affected negatively by anaemia (p = 0.0016) and positively by the carriage of multiple parasite genotypes (p = 0.04). Conclusions: In the search for correlates of protection against malaria, which will be essential to evaluate clinical trials of malaria vaccines based on MSP1, this study examines some potential assays and the factors that need to taken into account during their evaluation, using samples from individuals naturally exposed to malaria infection. © 2010 Ngoundou-Landji et al; licensee BioMed Central Ltd.
Bibliographic Details
Springer Science and Business Media LLC
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