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Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome

Pediatric Rheumatology, ISSN: 1546-0096, Vol: 9, Issue: 1, Page: 15
2011
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Article Description

Systemic juvenile idiopathic arthritis (sJIA) is a systemic inflammatory disease characterized by arthritis, spiking fever and a skin rash that is frequently complicated by macrophage activation syndrome (MAS), a life-threatening disorder. We report a 22-month-old girl with sJIA who developed severe MAS but was successfully treated with corticosteroids, cyclosporin A, and non-steroidal anti-inflammatory drugs by monitoring serum IL-18 levels. IL-18 is an extremely useful cytokine for monitoring the activity of sJIA and MAS, and serum IL-18 can be used as an indicator for the effectiveness of treatment and the decision to discontinue therapy.© 2011 Shigemura et al; licensee BioMed Central Ltd.

Bibliographic Details

Shigemura, Tomonari; Yamazaki, Takashi; Hara, Yosuke; Ou, Jing-Ni; Stevens, Anne M; Ochs, Hans D; Koike, Kenichi; Agematsu, Kazunaga

Springer Science and Business Media LLC

Medicine

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