Experimental infection of Bama miniature pigs with a highly virulent classical swine fever virus
Virology Journal, ISSN: 1743-422X, Vol: 8, Issue: 1, Page: 452
2011
- 11Citations
- 14Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef4
- Captures14
- Readers14
- 14
- Mentions1
- News Mentions1
- 1
Most Recent News
Quantitative analysis of viremia and viral shedding in pigs infected experimentally with classical swine fever virus isolates obtained from recent outbreaks in Japan
Abstract Although classical swine fever occurred in September 2018 for the first time in 26 years, its virulence is thought to be moderate based on field
Article Description
Background: Currently, larger domestic pigs are only animals widely used in vaccine evaluation and pathogenicity study of classical swine fever virus (CSFV). This study was aimed to create an alternative animal experimental infection model of CSFV. Results: Twenty specific-pathogen-free Bama miniature pigs were randomly divided into two groups and rooms, infected and non-infected, and the pigs in the infected group were inoculated intramuscularly with 10 , 10 or 10 TCID(median tissue culture infective dose) CSFV Shimen strain (n = 5 × 3) or left uninoculated to serve as in-contact pigs (n = 3). The uninfected control pigs (n = 2) were housed in a separate room. Clinical signs, body temperature, viraemia, tissue antigen distribution, pathological changes and seroconversion were monitored. Clinical signs were observed as early as 2 days post-inoculation (dpi) in all infected pigs (though mild in contact pigs), but not non-infected control pigs. All inoculated pigs showed viraemia by 6 dpi. The in-contact pigs showed lower levels of viraemia. At 10 dpi, seroconversion was noted in five of the 15 inoculated pigs. All inoculated or one in-contact pigs died by 15 dpi. Conclusions: These results show that Bama miniature pigs support productive CSFV infection and display clinical signs and pathological changes consistent with CSFV infections observed in larger domestic pigs. © 2011Sun et al; licensee BioMed Central Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80053172658&origin=inward; http://dx.doi.org/10.1186/1743-422x-8-452; http://www.ncbi.nlm.nih.gov/pubmed/21943299; http://virologyj.biomedcentral.com/articles/10.1186/1743-422X-8-452; https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-8-452; https://dx.doi.org/10.1186/1743-422x-8-452
Springer Nature
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