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Experimental infection of Bama miniature pigs with a highly virulent classical swine fever virus

Virology Journal, ISSN: 1743-422X, Vol: 8, Issue: 1, Page: 452
2011
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Quantitative analysis of viremia and viral shedding in pigs infected experimentally with classical swine fever virus isolates obtained from recent outbreaks in Japan

Abstract Although classical swine fever occurred in September 2018 for the first time in 26 years, its virulence is thought to be moderate based on field

Article Description

Background: Currently, larger domestic pigs are only animals widely used in vaccine evaluation and pathogenicity study of classical swine fever virus (CSFV). This study was aimed to create an alternative animal experimental infection model of CSFV. Results: Twenty specific-pathogen-free Bama miniature pigs were randomly divided into two groups and rooms, infected and non-infected, and the pigs in the infected group were inoculated intramuscularly with 10 , 10 or 10 TCID(median tissue culture infective dose) CSFV Shimen strain (n = 5 × 3) or left uninoculated to serve as in-contact pigs (n = 3). The uninfected control pigs (n = 2) were housed in a separate room. Clinical signs, body temperature, viraemia, tissue antigen distribution, pathological changes and seroconversion were monitored. Clinical signs were observed as early as 2 days post-inoculation (dpi) in all infected pigs (though mild in contact pigs), but not non-infected control pigs. All inoculated pigs showed viraemia by 6 dpi. The in-contact pigs showed lower levels of viraemia. At 10 dpi, seroconversion was noted in five of the 15 inoculated pigs. All inoculated or one in-contact pigs died by 15 dpi. Conclusions: These results show that Bama miniature pigs support productive CSFV infection and display clinical signs and pathological changes consistent with CSFV infections observed in larger domestic pigs. © 2011Sun et al; licensee BioMed Central Ltd.

Bibliographic Details

Sun, Yuan; Jiang, Qian; Tian, Da-Yong; Lin, Huan; Li, Hong; Han, Qiu-Ying; Han, Wen; Si, Chang-De; Hu, Shou-Ping; Zhang, Zhuo; Qu, Lian-Dong; Qiu, Hua-Ji

Springer Nature

Immunology and Microbiology; Medicine

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