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Genetic diversity of a Korean echovirus 5 isolate and response of the strain to five antiviral drugs

Virology Journal, ISSN: 1743-422X, Vol: 8, Issue: 1, Page: 79
2011
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Article Description

An outbreak of echovirus 5 (ECV 5) occurred in Korea in 2006, marking the first time this virus had been identified in the country since enterovirus surveillance began in 1993. Using a sample isolated from a young male patient with aseptic meningitis, we performed sequencing of the Korean ECV 5 strain and compared it with a prototype strain (Noyce). At the nucleotide level, the P1 region (85.3%) had the highest identity value; at the amino acid level, the P3 region (98.0%) had the highest identity value. The two strains shared all cleavage sites, with the exception of the VP1/2A site, which was TY/GA in the Noyce strain but TR/GA in the Korean ECV 5 isolate. In Vero cells infected with the Korean ECV 5 isolate, no cytotoxicity was observed in the presence of azidothymidine, acyclovir, amantadine, lamivudine, or ribavirin, when the drugs were administered at a CCvalue 100 g/mL. Of the five drugs, only amantadine (IC: 1 ± .42 μg/mL, TI: 100) and ribavirin (IC: 22 ± 1.36 μg/mL, TI: 4.55) had any antiviral activity against the Korean ECV 5 isolate. © 2011 Park et al; licensee BioMed Central Ltd.

Bibliographic Details

Park, Kwisung; Song, Jaehyoung; Baek, Kyoungah; Lee, Changgyun; Kim, Donguk; Cho, Samhyun; Park, Joonsoo; Choi, Youngjin; Kang, Byunghak; Choi, Hwajung; Cheon, Doo-Sung

Springer Science and Business Media LLC

Immunology and Microbiology; Medicine

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