Genetic diversity of a Korean echovirus 5 isolate and response of the strain to five antiviral drugs
Virology Journal, ISSN: 1743-422X, Vol: 8, Issue: 1, Page: 79
2011
- 8Citations
- 14Captures
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef6
- Captures14
- Readers14
- 14
Article Description
An outbreak of echovirus 5 (ECV 5) occurred in Korea in 2006, marking the first time this virus had been identified in the country since enterovirus surveillance began in 1993. Using a sample isolated from a young male patient with aseptic meningitis, we performed sequencing of the Korean ECV 5 strain and compared it with a prototype strain (Noyce). At the nucleotide level, the P1 region (85.3%) had the highest identity value; at the amino acid level, the P3 region (98.0%) had the highest identity value. The two strains shared all cleavage sites, with the exception of the VP1/2A site, which was TY/GA in the Noyce strain but TR/GA in the Korean ECV 5 isolate. In Vero cells infected with the Korean ECV 5 isolate, no cytotoxicity was observed in the presence of azidothymidine, acyclovir, amantadine, lamivudine, or ribavirin, when the drugs were administered at a CCvalue 100 g/mL. Of the five drugs, only amantadine (IC: 1 ± .42 μg/mL, TI: 100) and ribavirin (IC: 22 ± 1.36 μg/mL, TI: 4.55) had any antiviral activity against the Korean ECV 5 isolate. © 2011 Park et al; licensee BioMed Central Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79951855160&origin=inward; http://dx.doi.org/10.1186/1743-422x-8-79; http://www.ncbi.nlm.nih.gov/pubmed/21345236; https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-8-79; http://virologyj.biomedcentral.com/articles/10.1186/1743-422X-8-79; https://dx.doi.org/10.1186/1743-422x-8-79
Springer Science and Business Media LLC
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