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Similarity searches in genome-wide numerical data sets

Biology Direct, ISSN: 1745-6150, Vol: 1, Issue: 1, Page: 13
2006
  • 8
    Citations
  • 0
    Usage
  • 17
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Review Description

We present psi-square, a program for searching the space of gene vectors. The program starts with a gene vector, i.e., the set of measurements associated with a gene, and finds similar vectors, derives a probabilistic model of these vectors, then repeats search using this model as a query, and continues to update the model and search again, until convergence. When applied to three different pathway-discovery problems, psi-square was generally more sensitive and sometimes more specific than the ad hoc methods developed for solving each of these problems before. © 2006 Glazko et al; licensee BioMed Central Ltd.

Bibliographic Details

Glazko, Galina; Coleman, Michael; Mushegian, Arcady

Springer Science and Business Media LLC

Immunology and Microbiology; Agricultural and Biological Sciences; Mathematics; Biochemistry, Genetics and Molecular Biology

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