ORFeus: a computational method to detect programmed ribosomal frameshifts and other non-canonical translation events
BMC Bioinformatics, ISSN: 1471-2105, Vol: 24, Issue: 1, Page: 471
2023
- 1Citations
- 8Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations1
- Citation Indexes1
- Captures8
- Readers8
- Mentions1
- Blog Mentions1
- Blog1
Article Description
Background: In canonical protein translation, ribosomes initiate translation at a specific start codon, maintain a single reading frame throughout elongation, and terminate at the first in-frame stop codon. However, ribosomal behavior can deviate at each of these steps, sometimes in a programmed manner. Certain mRNAs contain sequence and structural elements that cause ribosomes to begin translation at alternative start codons, shift reading frame, read through stop codons, or reinitiate on the same mRNA. These processes represent important translational control mechanisms that can allow an mRNA to encode multiple functional protein products or regulate protein expression. The prevalence of these events remains uncertain, due to the difficulty of systematic detection. Results: We have developed a computational model to infer non-canonical translation events from ribosome profiling data. Conclusion: ORFeus identifies known examples of alternative open reading frames and recoding events across different organisms and enables transcriptome-wide searches for novel events.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85179337732&origin=inward; http://dx.doi.org/10.1186/s12859-023-05602-8; http://www.ncbi.nlm.nih.gov/pubmed/38093195; https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-023-05602-8; https://dx.doi.org/10.1186/s12859-023-05602-8
Springer Science and Business Media LLC
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