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Characterization of a novel multi-resistant Pseudomonas juntendi strain from China with chromosomal bla and a megaplasmid coharboring bla and bla

BMC Genomics, ISSN: 1471-2164, Vol: 25, Issue: 1, Page: 774
2024
  • 0
    Citations
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  • 16
    Captures
  • 1
    Mentions
  • 0
    Social Media
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Metrics Details

  • Captures
    16
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Article Description

Background: Pseudomonas juntendi is a newly identified opportunistic pathogen, of which we have limited understanding. P. juntendi strains are often multidrug resistant, which complicates clinical management of infection. Methods: A strain of Pseudomonas juntendi (strain L4326) isolated from feces was characterized by MALDI-TOF-MS and Average Nucleotide Identity BLAST. This strain was further subject to whole-genome sequencing and Maximum Likelihood phylogenetic analysis. The strain was phenotypically characterized by antimicrobial susceptibility testing and conjugation assays. Results: We have isolated the novel P. juntendi strain L4236, which was multidrug resistant, but retained sensitivity to amikacin. L4236 harbored a megaplasmid that encoded bla and a novel bla resistance gene variant. P. juntendi strain L4236 was phylogenetically related to P. juntendi strain SAMN30525517. Conclusion: A rare P. juntendi strain was isolated from human feces in southern China with a megaplasmid coharboring bla and bla. Antimicrobial selection pressures may have driven acquisition of drug-resistance gene mutations and carriage of the megaplasmid.

Bibliographic Details

Jiang, Shiman; Li, Yaling; Bi, Kefan; Yang, Sisi; Xia, He; Li, Shengjie; Chen, Hui; Li, Lanjuan

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

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